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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Vismodegib


* price without discount in nearest pharmacy. Price may vary.

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Vismodegib volume of distribution

Vismodegib has a volume of distribution of 16.4 to 26.6 L.

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What is Vismodegib

Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.

Vismodegib mechanism of action

Mutations of the Hedgehog pathway may results in uncontrolled proliferation of skin basal cells. Vismodegib binds to and inhibits the transmembrane protein Smoothened homologue (SMO) to inhibit the Hedgehog signalling pathway.

Dosage forms of Vismodegib

Capsuleoral150 mg/1
Capsuleoral150 mg
Prescription Generics


International Brands



Erivedge GDC-0449


Hoffmann La Roche Limited

CAS number






Affected organisms

Humans and other mammals

Indication of Vismodegib

Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation.

Toxicity of Vismodegib

Increased risk of embryo-fetal death and significant birth defects. Common adverse event include muscle spasms, alopecia, dysgeusia, weight loss, fatigue, nausea, diarrhea, decreased appetite, constipation, arthralgias, vomiting, and ageusia.

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