Save up -80% on Vismodegib

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Vismodegib

$

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Vismodegib volume of distribution

Vismodegib has a volume of distribution of 16.4 to 26.6 L.

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What is Vismodegib

Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.

Vismodegib mechanism of action

Mutations of the Hedgehog pathway may results in uncontrolled proliferation of skin basal cells. Vismodegib binds to and inhibits the transmembrane protein Smoothened homologue (SMO) to inhibit the Hedgehog signalling pathway.

Dosage forms of Vismodegib

FormRouteStrength
Capsuleoral150 mg/1
Capsuleoral150 mg
Prescription Generics

false

International Brands

Erivedge

Synonyms

Erivedge GDC-0449

Manufacturers

Hoffmann La Roche Limited

CAS number

879085-55-9

UNII

25X868M3DS

State

solid

Affected organisms

Humans and other mammals

Indication of Vismodegib

Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation.

Toxicity of Vismodegib

Increased risk of embryo-fetal death and significant birth defects. Common adverse event include muscle spasms, alopecia, dysgeusia, weight loss, fatigue, nausea, diarrhea, decreased appetite, constipation, arthralgias, vomiting, and ageusia.

RX24 Drugs Disclaimer: before buying a Vismodegib on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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