Save up -80% on Voriconazole
Note: this is a drug discount program, not an insurance plan.
2018 Price of Voriconazole
Vfend 50 mg tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Voriconazole coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Voriconazole every time. What are you waiting for? Claim your prescription drug card now!
Voriconazole volume of distribution
* 4.6 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Voriconazole
Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections.
Voriconazole mechanism of action
Voriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane.
Dosage forms of Voriconazole
|Injection, powder, lyophilized, for solution||intravenous||10 mg/mL|
|Powder and solventfor solution forinfusion||Intravenous use||200 mg|
|Powder for oralsuspension||Oral use||40 mg/ml|
Accord Healthcare Inc
Yeast and other fungi
Indication of Voriconazole
For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by iScedosporium apiospermum /i and iFusarium /i spp.
Toxicity of Voriconazole
The minimum lethal oral dose in mice and rats was 300 mg/kg (equivalent to 4 and 7 times the recommended maintenance dose (RMD), based on body surface area). At this dose, clinical signs observed in both mice and rats included salivation, mydriasis, titubation (loss of balance while moving), depressed behavior, prostration, partially closed eyes, and dyspnea. Other signs in mice were convulsions, corneal opacification and swollen abdomen.
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