Save up -80% on Voriconazole

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Voriconazole

Vfend 50 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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Voriconazole volume of distribution

* 4.6 L/kg

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What is Voriconazole

Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections.

Voriconazole mechanism of action

Voriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane.

Dosage forms of Voriconazole

Form Route Strength
Injection, powder, lyophilized, for solution intravenous 10 mg/mL
Powder and solventfor solution forinfusion Intravenous use 200 mg
Powder for oralsuspension Oral use 40 mg/ml
Prescription Generics


International Brands



(AlphaR,betas)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (R-(R*,s*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol


Accord Healthcare Inc

CAS number






Affected organisms

Yeast and other fungi

Indication of Voriconazole

For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by iScedosporium apiospermum /i and iFusarium /i spp.

Toxicity of Voriconazole

The minimum lethal oral dose in mice and rats was 300 mg/kg (equivalent to 4 and 7 times the recommended maintenance dose (RMD), based on body surface area). At this dose, clinical signs observed in both mice and rats included salivation, mydriasis, titubation (loss of balance while moving), depressed behavior, prostration, partially closed eyes, and dyspnea. Other signs in mice were convulsions, corneal opacification and swollen abdomen.

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