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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Vorinostat

Zolinza 100 mg capsule

$83.11

capsule

* price without discount in nearest pharmacy. Price may vary.

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Vorinostat volume of distribution

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What is Vorinostat

Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new class of agents known as histone deacetylase inhibitors. A recent study suggested that vorinostat also possesses some activity against recurrent glioblastoma multiforme, resulting in a median overall survival of 5.7 months (compared to 4 – 4.4 months in earlier studies). Further brain tumor trials are planned in which vorinostat will be combined with other drugs.[Wikipedia]

Vorinostat mechanism of action

Vorinostat inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50-lt; 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized.

Dosage forms of Vorinostat

FormRouteStrength
Capsuleoral100 mg/1
Capsuleoral100 mg
Prescription Generics

false

International Brands

Zolinza

Synonyms

Octanedioic acid hydroxyamide phenylamide SAHA

Manufacturers

Merck Canada Inc

CAS number

149647-78-9

UNII

58IFB293JI

State

solid

Affected organisms

Humans and other mammals

Indication of Vorinostat

For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.

Toxicity of Vorinostat

RX24 Drugs Disclaimer: before buying a Vorinostat on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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