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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Trintellix

$167

5mg

* price without discount in nearest pharmacy. Price may vary.

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Vortioxetine volume of distribution

The apparent volume of distribution of vortioxetine is approximately 2600 L, indicating extensive extravascular distribution.

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What is Vortioxetine

Vortioxetine is an atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and simulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake of serotonin. More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. SMSs were developed because there are many different subtypes of serotonin receptors, however, not all of these receptors appear to be involved in the antidepressant effects of SRIs. Some serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional role in the efficacy of SRIs in treating depression.

Vortioxetine mechanism of action

Vortioxetine is classified as a serotonin modulator and simulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake of serotonin. More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, while also acting as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors.

Dosage forms of Vortioxetine

DrugDosageQuantityPrice
Trintellix5mg28 Tablet$167.00
Trintellix5mg84 Tablet$475.00
Trintellix10mg28 Tablet$170.00
Trintellix10mg84 Tablet$428.00
Trintellix20mg56 Tablet$295.00
Trintellix20mg84 Tablet$428.00
Prescription Generics

false

International Brands

Brintellix

Synonyms

4-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazin-1-ium vortioxetine cation

Manufacturers

Avera Mc Kennan Hospital

CAS number

508233-74-7

UNII

3O2K1S3WQV

State

solid

Affected organisms

Indication of Vortioxetine

Vortioxetine is indicated for the treatment of major depressive disorder (MDD).

Toxicity of Vortioxetine

The most commonly reported adverse effects during clinical trials were nausea, diarrhea, and dry mouth. The FDA label includes a blackbox warning for the following risks and complications: serotonin syndrome, especially when combined with other serotonergic agents; increased risk of abnormal bleeding, especially when combined with NSAIDs, aspirin, or other drugs that affect coagulation; activation of mania/hypomania; hyponatremia; and suicidal thoughts and behaviour in children, adolescents, and young adults.

RX24 Drugs Disclaimer: before buying a Vortioxetine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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