Save up -80% on Zafirlukast
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2018 Price of Zafirlukast
Accolate 20 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Zafirlukast volume of distribution
* 70 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Zafirlukast
Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily. Zafirlukast blocks the action of the cysteinyl leukotrienes on the CysLT1 receptors, thus reducing constriction of the airways, build-up of mucus in the lungs and inflammation of the breathing passages.
Zafirlukast mechanism of action
Zafirlukast is a selective and competitive receptor antagonist of leukotriene D4 and E4 (LTD sub4 /sub and LTE4), components of slow-reacting substance of anaphylaxis (SRSA). Cysteinyl leukotriene production and receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle constriction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.
Dosage forms of Zafirlukast
Par Pharmaceutical Inc.
Humans and other mammals
Indication of Zafirlukast
For the prophylaxis and chronic treatment of asthma.
Toxicity of Zafirlukast
Side effects include rash and upset stomach.
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