Save up -80% on Zalcitabine

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Zalcitabine

Hivid 0.375 mg tablet

$2.27

tablet

* price without discount in nearest pharmacy. Price may vary.

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Zalcitabine volume of distribution

* 0.304 to 0.734 L/kg

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What is Zalcitabine

A dideoxynucleoside compound in which the 3′-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5′ to 3′ phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.

Zalcitabine mechanism of action

Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Within cells, zalcitabine is converted to its active metabolite, dideoxycytidine 5′-triphosphate (ddCTP), by the sequential action of cellular enzymes. ddCTP interferes with viral RNA-directed DNA polymerase (reverse transcriptase) by competing for utilization of the natural substrate deoxycytidine 5′-triphosphate (dCTP), as well as incorpating into viral DNA. Due to it’s lack of a 3′-OH group, the formation of a 5′ to 3′ phosphodiester linkage that is necessary for DNA chain elongation is inhibited, thus leading to the termination of viral DNA growth.

Dosage forms of Zalcitabine

FormRouteStrength
Tabletoral.375 mg
Tabletoral.75 mg
Prescription Generics

false

International Brands

Hivid Tab 0.375mg

Synonyms

2′,3′-Dideoxycytidine 4-amino-1-((2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Manufacturers

Hoffmann La Roche Limited

CAS number

7481-89-2

UNII

6L3XT8CB3I

State

solid

Affected organisms

Human Immunodeficiency Virus

Indication of Zalcitabine

For the treatment of Human immunovirus (HIV) infections in conjunction with other antivirals.

Toxicity of Zalcitabine

Acute overdose: Inadvertent pediatric overdoses have occurred with doses up to 1.5 mg/kg zalcitabine. Chronic overdose: in an initial dose-finding study in which zalcitabine was administered at doses 25 times (0.25 mg/kg every 8 hours) the currently recommended dose, one patient discontinued zalcitabine after 1 weeks of treatment subsequent to the development of a rash and fever.

RX24 Drugs Disclaimer: before buying a Zalcitabine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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