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Price of Zidovudine
Retrovir iv infusion vial
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Zidovudine volume of distribution
Apparent volume of distribution, HIV-infected patients, IV administration = 1.6 0.6 L/kg
What is Zidovudine
A dideoxynucleoside compound in which the 3 #39;-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. (PubChem)
Zidovudine mechanism of action
Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5.-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase . and ..
Dosage forms of Zidovudine
|Tablet, film coated||oral|
|Tablet, film coated||oral||150 mg/1|
Abacavir Sulfate, Lamivudine and Zidovudine
Human Immunodeficiency Virus
Indication of Zidovudine
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
Toxicity of Zidovudine
Symptoms of overdose include fatigue, headache, nausea, and vomiting. LD sub50 /sub is 3084 mg/kg (orally in mice).
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