Save up -80% on Zidovudine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Retrovir
|price without discount in nearest pharmacy. Price may vary.|
We offer free Retrovir coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Zidovudine every time. What are you waiting for? Claim your prescription drug card now!
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Zidovudine volume of distribution
Zidovudine AUC was similar when a single dose of zidovudine was administered with food. Protein Binding 34-38% Volume of Distribution 1.6 L/kg CSF:Plasma ratio 0.5 Semen:Plasma ratio 5.9 (0.95-13.5) Renal Clearance Greatly exceeds creatinine clearance, indicating that significant tubular secretion takes place.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Zidovudine
A dideoxynucleoside compound in which the 3 #39;-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
Zidovudine mechanism of action
Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5.-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase . and ..
Dosage forms of Zidovudine
|Retrovir Syrup||10mg/mL||240mL Oral suspension||$85.00|
Human Immunodeficiency Virus
Indication of Zidovudine
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
Toxicity of Zidovudine
Symptoms of overdose include fatigue, headache, nausea, and vomiting. LD sub50 /sub is 3084 mg/kg (orally in mice).
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