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Price of Zolpidem
Zolpidem tartrate 10 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Zolpidem volume of distribution
What is Zolpidem
Zolpidem is a prescription short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to benzodiazepine receptors which are located on the gamma-aminobutyric acid receptors. Zolpidem is used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). It is classified as an imidazopyridine. As an anticonvulsant and muscle relaxant, the beneficial effects start to emerge at 10 and 20 times the dose required for sedation, respectively. For that reason, it has never been approved for either muscle relaxation or seizure prevention. Recently, zolpidem has been cited in various medical reports mainly in the United Kingdom as waking persistent vegetative state (PVS) patients, and dramatically improving the conditions of people with brain injuries. (Wikipedia)
Zolpidem mechanism of action
Zolpidem modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABA subA /sub receptor chloride channel macromolecular complex. Unlike the benzodiazepines, which non-selectively interact with all three alpha-receptor subtypes, Zolpidem preferentially binds to the alpha-1 receptor.
Dosage forms of Zolpidem
|Tablet, coated||oral||12.5 mg/1|
|Tablet, coated||oral||6.25 mg/1|
A S Medication Solutions Llc
Humans and other mammals
Indication of Zolpidem
For the short-term treatment of insomnia.
Toxicity of Zolpidem
Oral (male rat) LD sub50 /sub = 695 mg/kg. Symptoms of overdose include impairment of consciousness ranging from somnolence to light coma.
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