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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zonegran

$24.12120 capsules/100 mg
Price with discount in nearest pharmacy. Price may vary.

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Zonisamide volume of distribution

The elimination half-life of zonisamide in RBC is approximately 105 hours. The apparent volume of distribution (V/F) of zonisamide is about 1.45 L/kg following a 400 mg oral dose. Zonisamide, at concentrations of 1.0–7.0 µg/mL, is approximately 40% bound to human plasma proteins.

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2018 Statistics

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Total savings $4,735,080

What is Zonisamide

Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.

Zonisamide mechanism of action

Zonisamide binds to sodium channels and voltage sensitive calcium channels, which suppresses neuronal depolarization and hypersynchronization. Zonisamide also inhibits carbonic anhydrase to a weaker extent, but such an effect is not thought to contribute substantially to the drug’s anticonvulsant activity.

Dosage forms of Zonisamide

Orodispersible tabletOral use100 mg
Orodispersible tabletOral use25 mg
Orodispersible tabletOral use300 mg

Prescription Generics


International Brands



1,2-Benzisoxazole-3-methanesulfonamide 3-(Sulfamoylmethyl)-1,2-benzisoxazole


Concordia Pharmaceuticals Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Zonisamide

For use as adjunctive treatment of partial seizures in adults with epilepsy.

Toxicity of Zonisamide

Symptoms of overdose include diminished breathing, loss of consciousness, low blood pressure, and slow heartbeat.

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