Save up -80% on Zonisamide
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2018 Price of Zonisamide
Zonisamide 50 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Zonisamide volume of distribution
* 1.45 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Zonisamide
Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
Zonisamide mechanism of action
Zonisamide binds to sodium channels and voltage sensitive calcium channels, which suppresses neuronal depolarization and hypersynchronization. Zonisamide also inhibits carbonic anhydrase to a weaker extent, but such an effect is not thought to contribute substantially to the drug’s anticonvulsant activity.
Dosage forms of Zonisamide
|Orodispersible tablet||Oral use||100 mg|
|Orodispersible tablet||Oral use||25 mg|
|Orodispersible tablet||Oral use||300 mg|
Concordia Pharmaceuticals Inc.
Humans and other mammals
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