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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Zonisamide

Zonisamide 50 mg capsule

$1.12

capsule

* price without discount in nearest pharmacy. Price may vary.

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Zonisamide volume of distribution

* 1.45 L/kg

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What is Zonisamide

Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.

Zonisamide mechanism of action

Zonisamide binds to sodium channels and voltage sensitive calcium channels, which suppresses neuronal depolarization and hypersynchronization. Zonisamide also inhibits carbonic anhydrase to a weaker extent, but such an effect is not thought to contribute substantially to the drug’s anticonvulsant activity.

Dosage forms of Zonisamide

FormRouteStrength
Orodispersible tabletOral use100 mg
Orodispersible tabletOral use25 mg
Orodispersible tabletOral use300 mg
Prescription Generics

false

International Brands

Zonegran

Synonyms

1,2-Benzisoxazole-3-methanesulfonamide 3-(Sulfamoylmethyl)-1,2-benzisoxazole

Manufacturers

Concordia Pharmaceuticals Inc.

CAS number

68291-97-4

UNII

459384H98V

State

solid

Affected organisms

Humans and other mammals

Indication of Zonisamide

For use as adjunctive treatment of partial seizures in adults with epilepsy.

Toxicity of Zonisamide

Symptoms of overdose include diminished breathing, loss of consciousness, low blood pressure, and slow heartbeat.

RX24 Drugs Disclaimer: before buying a Zonisamide on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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