Save up -80% on Zonisamide
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Zonegran
|$24.12||120 capsules/100 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Zonisamide coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Zonisamide every time. What are you waiting for? Claim your prescription drug card now!
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Zonisamide volume of distribution
The elimination half-life of zonisamide in RBC is approximately 105 hours. The apparent volume of distribution (V/F) of zonisamide is about 1.45 L/kg following a 400 mg oral dose. Zonisamide, at concentrations of 1.0–7.0 µg/mL, is approximately 40% bound to human plasma proteins.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Zonisamide
Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
Zonisamide mechanism of action
Zonisamide binds to sodium channels and voltage sensitive calcium channels, which suppresses neuronal depolarization and hypersynchronization. Zonisamide also inhibits carbonic anhydrase to a weaker extent, but such an effect is not thought to contribute substantially to the drug’s anticonvulsant activity.
Dosage forms of Zonisamide
|Orodispersible tablet||Oral use||100 mg|
|Orodispersible tablet||Oral use||25 mg|
|Orodispersible tablet||Oral use||300 mg|
Concordia Pharmaceuticals Inc.
Humans and other mammals
Indication of Zonisamide
For use as adjunctive treatment of partial seizures in adults with epilepsy.
Toxicity of Zonisamide
Symptoms of overdose include diminished breathing, loss of consciousness, low blood pressure, and slow heartbeat.
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