Antimicrobials are one of the most widely prescribed groups of medicines in urology. Especially often, AP is used for urinary tract infections, postoperative, nosocomial, including catheter-associated infections, infections, sexually transmitted infections, and for antibiotic prophylaxis.
Effective use of antimicrobial drugs in urology is limited by the growth of antibiotic resistance, which sharply limits the choice of drugs for effective antibiotic therapy.
Local antimicrobials can disrupt the balance of microflora as well as systemic antibiotics. In addition to the disastrous effect on pathogenic bacteria and other “bad” microorganisms, they can significantly reduce the number of beneficial bacteria.
After the application of antimicrobial drugs, in the absence of the second stage of treatment aimed at restoring the numerical superiority of bacteria, discomfort phenomena can be noted. The reason is the dysbiosis of the microflora. Also, in the absence of a sufficient number of lactobacilli, there is a high risk of recurrence of the disease and inflammatory process.