Neuraminidase (sialidase) is one of the key enzymes involved in the replication of influenza A and B viruses. When the neuraminidase is inhibited, the ability of viruses to penetrate into healthy cells is disrupted, the yield of virions from the infected cell is inhibited, and their resistance to inactivating action of the mucous secretion of the airways decreases.
Due to a special mechanism of action, neuraminidase inhibitors prevent the spread of infection from a sick person to a healthy one. Also, neuraminidase inhibitors can reduce cytokine production by inhibiting the development of local inflammatory response and weakening systemic manifestations of a viral infection such as fever, muscle and joint pain, loss of appetite.
Neuraminidase inhibitors reduce the resistance of viruses to the protective effect of the secretion of the respiratory tract, which prevents further spread of the virus in the body.