Recent research has shown that PMDD can be associated with a low level of serotonin, a chemical element in the brain that helps transmit neural signals. Certain brain cells that use serotonin are responsible for mood, sleep, and pain. In this regard, constant changes in the level of serotonin can cause the appearance of the premenstrual dysphoric syndrome.
Irritability, mood swings, anxiety, inner psychological tension, depression, fatigue, edema, headache and dizziness, increased appetite and weight gain, nausea, abdominal pain, chest pain, and its swelling – this is the basic physical and emotional symptoms of premenstrual syndrome.
If the situation is not simple, then for the treatment of PMS most often used drugs based on female sex hormones, as well as non-steroidal anti-inflammatory drugs that help cope with physical pain and special drugs that normalize the psycho-emotional sphere.
To date, based on scientific data, two different approaches have been developed. One of them is the direct effect on the receptors of the central nervous system. For example, some antidepressants may be prescribed to treat the emotional symptoms of PMDD.
Other therapeutic approaches aim to prevent ovulation Suppression of ovulation can be achieved, for example, with combined oral contraceptives (COCs). The problem is that the COC contains a synthetic progesterone component (progestin), which, like natural progesterone, can aggravate or even cause the symptoms of PMDD, despite the oppression of ovulation.
To date, the market for hormonal contraceptives exists and those that have, in addition to contraception, a registered indication – treatment of PMDD. Such preparations contain progestin, which possesses an antimineralocorticoid property, due to which the symptoms of PMDD are alleviated.